InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPH2

Summary

InnateDB Protein

IDBP-48340.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPH2

Protein Name

tryptophan hydroxylase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000329093

InnateDB Gene

IDBG-48338 (TPH2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Attention deficit-hyperactivity disorder 7 (ADHD7) [MIM:613003]: A neurobehavioral developmental disorder primarily characterized by the coexistence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. {ECO:0000269PubMed:18347598}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.

Tissue Specificity

Brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004510	tryptophan 5-monooxygenase activity
GO:0005506	iron ion binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0007623	circadian rhythm
GO:0008152	metabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0014823	response to activity
GO:0031667	response to nutrient levels
GO:0034641	cellular nitrogen compound metabolic process
GO:0042427	serotonin biosynthetic process
GO:0043627	response to estrogen
GO:0044281	small molecule metabolic process
GO:0046219	indolalkylamine biosynthetic process
GO:0051384	response to glucocorticoid
GO:0051592	response to calcium ion
GO:0055114	oxidation-reduction process
GO:0071285	cellular response to lithium ion

Cellular Component

GO:0005829	cytosol
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR002912 ACT domain
IPR005963 Tryptophan 5-monooxygenase
IPR019773 Tyrosine 3-monooxygenase-like
IPR019774 Aromatic amino acid hydroxylase, C-terminal

PFAM

PF01842
PF00351

PRINTS

PR00372

PIRSF

PIRSF000336

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt