InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LSAMP

Summary

InnateDB Protein

IDBP-483410.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LSAMP

Protein Name

limbic system-associated membrane protein

Synonyms

IGLON3; LAMP;

Species

Homo sapiens

Ensembl Protein

ENSP00000419000

InnateDB Gene

IDBG-50984 (LSAMP)

Protein Structure

UniProt Annotation

Function

Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007399	nervous system development
GO:0035641	locomotory exploration behavior

Cellular Component

GO:0005886	plasma membrane
GO:0031225	anchored component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13449