InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDXK

Summary

InnateDB Protein

IDBP-4835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDXK

Protein Name

pyridoxal (pyridoxine, vitamin B6) kinase

Synonyms

C21orf124; C21orf97; HEL-S-1a; PKH; PNK;

Species

Homo sapiens

Ensembl Protein

ENSP00000291565

InnateDB Gene

IDBG-4833 (PDXK)

Protein Structure

UniProt Annotation

Function

Required for synthesis of pyridoxal-5-phosphate from vitamin B6.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 3 is detected in adult testis and spermatozoa.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008478	pyridoxal kinase activity
GO:0030170	pyridoxal phosphate binding
GO:0030955	potassium ion binding
GO:0031402	sodium ion binding
GO:0031403	lithium ion binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0008283	cell proliferation
GO:0009443	pyridoxal 5'-phosphate salvage
GO:0016310	phosphorylation
GO:0042816	vitamin B6 metabolic process
GO:0042823	pyridoxal phosphate biosynthetic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004625 Pyridoxal phosphate (active vitamin B6) biosynthesis, pyridoxal kinase
IPR011611 Carbohydrate kinase PfkB
IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase
IPR029056 Ribokinase-like

PFAM

PF00294
PF08543

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00764

PhosphoSite