InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNIP1

Summary

InnateDB Protein

IDBP-483535.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNIP1

Protein Name

Kv channel interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000431102

InnateDB Gene

IDBG-57271 (KCNIP1)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface. {ECO:0000269PubMed:10676964, ECO:0000269PubMed:11423117, ECO:0000269PubMed:12829703}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005267	potassium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0005513	detection of calcium ion
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0071805	potassium ion transmembrane transport