InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP12

Summary

InnateDB Protein

IDBP-483819.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP12

Protein Name

caspase 12 (gene/pseudogene)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000424963

InnateDB Gene

IDBG-69532 (CASP12)

Protein Structure

UniProt Annotation

Function

Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. {ECO:0000269PubMed:12054529, ECO:0000269PubMed:15129283}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. {ECO:0000269PubMed:12054529}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress