InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALCAM

Summary

InnateDB Protein

IDBP-48385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALCAM

Protein Name

activated leukocyte cell adhesion molecule

Synonyms

CD166; MEMD;

Species

Homo sapiens

Ensembl Protein

ENSP00000305988

InnateDB Gene

IDBG-48383 (ALCAM)

Protein Structure

UniProt Annotation

Function

Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.

Subcellular Localization

Membrane; Single-pass type I membrane protein.Isoform 3: Secreted {ECO:0000269PubMed:15496415}.

Disease Associations

Tissue Specificity

Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines. {ECO:0000269PubMed:9502422}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0008045	motor neuron axon guidance

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13740