Version 5.4
Homo sapiens Protein: CD200R1
Summary
InnateDB Protein IDBP-483972.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD200R1
Protein Name CD200 receptor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000418801
InnateDB Gene IDBG-50029 (CD200R1)
Protein Structure
UniProt Annotation
Function Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. {ECO:0000269PubMed:12960329}.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 4: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.
Disease Associations
Tissue Specificity Expressed in granulocytes, monocytes, most T- cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells. {ECO:0000269PubMed:12960329}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0016032 viral process
GO:0050776 regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TD46
PhosphoSite PhosphoSite-Q8TD46
TrEMBL
UniProt Splice Variant
Entrez Gene 131450
UniGene Hs.607669
RefSeq NP_620386
HUGO HGNC:24235
OMIM 607546
CCDS CCDS54623
HPRD 09609
IMGT
EMBL AC074044 AF283760 AF495380 AF497548 AF497549 AF497550 AK126349 AK293071 AY284975 AY358910 BC069661 BC069721 BC069743 BC093890 CH471052
GenPept AAH69661 AAH69721 AAH69743 AAH93890 AAM14622 AAM16157 AAM16158 AAM16159 AAN61171 AAQ19772 AAQ89269 BAF85760 BAG54311 EAW79657 EAW79658

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca