Version 5.4
Homo sapiens Protein: PKD2L2
Summary
InnateDB Protein IDBP-484095.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKD2L2
Protein Name polycystic kidney disease 2-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000424725
InnateDB Gene IDBG-46349 (PKD2L2)
Protein Structure
UniProt Annotation
Function May function as a subunit of a cation channel and play a role in fertilization.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity According to PubMed:10602361, expressed only in testis. According to PubMed:10756092, expressed also in brain and kidney. Isoform 2 is found only in transformed lymphoblasts. Isoform 3 is found in all tissues tested.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
Biological Process
GO:0006811 ion transport
GO:0008150 biological_process
GO:0050982 detection of mechanical stimulus
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
PFAM PF00520
PF08016
PRINTS PR01433
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NZM6
PhosphoSite PhosphoSite-Q9NZM6
TrEMBL D6RF71
UniProt Splice Variant
Entrez Gene 27039
UniGene Hs.716884
RefSeq NP_001287850
HUGO HGNC:9012
OMIM 604669
CCDS
HPRD 05238
IMGT
EMBL AC106753 AC106791 AF118125 AF182034 AK301924 BC044581 CH471062
GenPept AAD46478 AAF65622 AAH44581 BAG63344 EAW62174

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca