InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCSK1

Summary

InnateDB Protein

IDBP-484111.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCSK1

Protein Name

proprotein convertase subtilisin/kexin type 1

Synonyms

BMIQ12; NEC1; PC1; PC3; SPC3;

Species

Homo sapiens

Ensembl Protein

ENSP00000421600

InnateDB Gene

IDBG-34238 (PCSK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007267	cell-cell signaling
GO:0008152	metabolic process
GO:0016486	peptide hormone processing
GO:0043043	peptide biosynthetic process
GO:0044267	cellular protein metabolic process
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005615	extracellular space
GO:0005794	Golgi apparatus
GO:0030133	transport vesicle
GO:0034774	secretory granule lumen

Protein Structure and Domains

PDB ID

InterPro

IPR000209 Peptidase S8/S53 domain
IPR002884 Proprotein convertase, P
IPR008979 Galactose-binding domain-like
IPR009020 Proteinase inhibitor, propeptide
IPR015500 Peptidase S8, subtilisin-related
IPR022005 Prohormone convertase enzyme

PFAM

PF00082
PF01483
PF12177

PRINTS

PR00723

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29120