InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IDO1

Summary

InnateDB Protein

IDBP-484112.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDO1

Protein Name

indoleamine 2,3-dioxygenase 1

Synonyms

IDO; IDO-1; INDO;

Species

Homo sapiens

Ensembl Protein

ENSP00000430950

InnateDB Gene

IDBG-18750 (IDO1)

Protein Structure

UniProt Annotation

Function

Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. {ECO:0000269PubMed:17671174}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	5 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004833	tryptophan 2,3-dioxygenase activity
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0033754	indoleamine 2,3-dioxygenase activity
GO:0046872	metal ion binding

Biological Process

GO:0002534	cytokine production involved in inflammatory response
GO:0002666	positive regulation of T cell tolerance induction
GO:0002678	positive regulation of chronic inflammatory response
GO:0002830	positive regulation of type 2 immune response
GO:0006569	tryptophan catabolic process
GO:0006954	inflammatory response
GO:0007565	female pregnancy
GO:0019441	tryptophan catabolic process to kynurenine
GO:0032496	response to lipopolysaccharide
GO:0032693	negative regulation of interleukin-10 production
GO:0032735	positive regulation of interleukin-12 production
GO:0033555	multicellular organismal response to stress
GO:0034276	kynurenic acid biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0036269	swimming behavior
GO:0042130	negative regulation of T cell proliferation
GO:0043065	positive regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0046007	negative regulation of activated T cell proliferation
GO:0055114	oxidation-reduction process
GO:0070233	negative regulation of T cell apoptotic process