Version 5.4
Homo sapiens Protein: CR1L
Summary
InnateDB Protein IDBP-484234.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CR1L
Protein Name complement component (3b/4b) receptor 1-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000421736
InnateDB Gene IDBG-106367 (CR1L)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14687939}. Membrane {ECO:0000269PubMed:14687939}. Secreted {ECO:0000269PubMed:14687939}. Note=Predominantly found in association with the membrane fraction, but also located in the cytoplasm and in the supernatant.
Disease Associations
Tissue Specificity Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue. {ECO:0000269PubMed:14687939}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR000436 Sushi/SCR/CCP
PFAM PF00084
PRINTS
PIRSF
SMART SM00032
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2VPA4
PhosphoSite PhosphoSite-Q2VPA4
TrEMBL
UniProt Splice Variant
Entrez Gene 1379
UniGene Hs.655194
RefSeq NP_783641
HUGO HGNC:2335
OMIM 605886
CCDS CCDS44310
HPRD
IMGT
EMBL AL137789 AL365178 AY114160 BC109190 BC109191
GenPept AAI09191 AAI09192 AAM47024

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca