InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ESYT3

Summary

InnateDB Protein

IDBP-484313.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESYT3

Protein Name

extended synaptotagmin-like protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000417388

InnateDB Gene

IDBG-58437 (ESYT3)

Protein Structure

UniProt Annotation

Function

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. {ECO:0000250, ECO:0000269PubMed:23791178}.

Subcellular Localization

Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Detected at sites of contact between the endoplasmic reticulum membrane and the cell membrane. Recruited to the cell membrane via the third C2 domain.

Disease Associations

Tissue Specificity

Widely expressed with high level in cerebellum and skin. {ECO:0000269PubMed:17360437}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0046872	metal ion binding

Biological Process

GO:0006869

lipid transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0031227	intrinsic component of endoplasmic reticulum membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0044232	organelle membrane contact site