InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFNE

Summary

InnateDB Protein

IDBP-484340.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNE

Protein Name

interferon, epsilon

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418018

InnateDB Gene

IDBG-54354 (IFNE)

Protein Structure

UniProt Annotation

Function

Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Endometrium-specific. {ECO:0000269PubMed:23449591}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005132	type I interferon receptor binding

Biological Process

GO:0002250	adaptive immune response
GO:0002286	T cell activation involved in immune response
GO:0002323	natural killer cell activation involved in immune response
GO:0006952	defense response
GO:0006959	humoral immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0030183	B cell differentiation
GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0042100	B cell proliferation
GO:0042742	defense response to bacterium
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response
GO:0045343	regulation of MHC class I biosynthetic process
GO:0051607	defense response to virus