InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ENOPH1

Summary

InnateDB Protein

IDBP-484499.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ENOPH1

Protein Name

enolase-phosphatase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000427209

InnateDB Gene

IDBG-27068 (ENOPH1)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene). {ECO:0000255HAMAP-Rule:MF_03117, ECO:0000269PubMed:15843022}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03117}. Nucleus {ECO:0000255HAMAP-Rule:MF_03117}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0016787	hydrolase activity
GO:0043874	acireductone synthase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0006595	polyamine metabolic process
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0019509	L-methionine biosynthetic process from methylthioadenosine
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process