Version 5.4
Homo sapiens Protein: ECSCR
Summary
InnateDB Protein IDBP-484514.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECSCR
Protein Name endothelial cell-specific chemotaxis regulator
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000421364
InnateDB Gene IDBG-409336 (ECSCR)
Protein Structure
UniProt Annotation
Function Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000269PubMed:18556573, ECO:0000269PubMed:19416853}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Disease Associations
Tissue Specificity Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells. {ECO:0000269PubMed:18556573, ECO:0000269PubMed:19416853}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q19T08
PhosphoSite PhosphoSite-Q19T08
TrEMBL
UniProt Splice Variant
Entrez Gene 641700
UniGene Hs.570903
RefSeq NP_001280668
HUGO HGNC:35454
OMIM 615736
CCDS CCDS75317
HPRD
IMGT
EMBL AK304726 BC146912 BC146913 DQ462572 EU025066
GenPept AAI46913 AAI46914 ABE73209 ABW05062 BAG65489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca