InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPP2

Summary

InnateDB Protein

IDBP-48460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPP2

Protein Name

tripeptidyl peptidase II

Synonyms

TPP-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000365233

InnateDB Gene

IDBG-48458 (TPP2)

Protein Structure

UniProt Annotation

Function

Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19747897}. Nucleus {ECO:0000269PubMed:19747897}. Note=Translocates to the nucleus in responce to gamma-irradiation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	8 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004177	aminopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0008240	tripeptidyl-peptidase activity
GO:0042277	peptide binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006508	proteolysis
GO:0045087	innate immune response (InnateDB)