InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EME1

Summary

InnateDB Protein

IDBP-484689.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EME1

Protein Name

essential meiotic endonuclease 1 homolog 1 (S. pombe)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000421700

InnateDB Gene

IDBG-58503 (EME1)

Protein Structure

UniProt Annotation

Function

Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269PubMed:12686547, ECO:0000269PubMed:12721304, ECO:0000269PubMed:14617801, ECO:0000269PubMed:17289582}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:14617801}. Note=Recruited to regions of DNA damage in S-phase cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0072429	response to intra-S DNA damage checkpoint signaling
GO:0090305	nucleic acid phosphodiester bond hydrolysis