Version 5.4
Homo sapiens Protein: POLK
Summary
InnateDB Protein IDBP-484695.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLK
Protein Name polymerase (DNA directed) kappa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000424174
InnateDB Gene IDBG-29209 (POLK)
Protein Structure
UniProt Annotation
Function DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. {ECO:0000269PubMed:10620008, ECO:0000269PubMed:11024016, ECO:0000269PubMed:12145297, ECO:0000269PubMed:12444249, ECO:0000269PubMed:12952891, ECO:0000269PubMed:14630940, ECO:0000269PubMed:15533436}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12414988}. Note=Detected throughout the nucleus and at replication foci.
Disease Associations
Tissue Specificity Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. {ECO:0000269PubMed:10518552, ECO:0000269PubMed:10620008}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006297 nucleotide-excision repair, DNA gap filling
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001126 DNA-repair protein, UmuC-like
IPR017961 DNA polymerase, Y-family, little finger domain
IPR017963 DNA-repair protein, UmuC-like, N-terminal
IPR024728 DNA polymerase type-Y, HhH motif
PFAM PF00817
PF11799
PF11798
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBT6
PhosphoSite PhosphoSite-Q9UBT6
TrEMBL D6RDX9
UniProt Splice Variant
Entrez Gene 51426
UniGene Hs.732105
RefSeq
HUGO HGNC:9183
OMIM 605650
CCDS
HPRD 09291
IMGT
EMBL AB027564 AB036934 AB036935 AC010245 AC026424 AC116341 AF163570 AF194973 AF315602 AF318313 AK091659 AK314610 AY273797 AY769929 AY769930 AY769931 AY769932 BC014955 BC050718 CH471084
GenPept AAF02540 AAF23270 AAH14955 AAH50718 AAN15780 AAN15781 AAP12648 AAV80827 AAV80828 AAV80829 AAV80830 BAA86943 BAB58975 BAB58976 BAC03714 BAG37179 EAW95763

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca