Version 5.4
Homo sapiens Protein: PTPLAD2
Summary
InnateDB Protein IDBP-484708.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPLAD2
Protein Name protein tyrosine phosphatase-like A domain containing 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419503
InnateDB Gene IDBG-53437 (PTPLAD2)
Protein Structure
UniProt Annotation
Function Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. {ECO:0000269PubMed:18554506}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:18554506}; Multi-pass membrane protein {ECO:0000269PubMed:18554506}.
Disease Associations
Tissue Specificity Highly expressed in leukocytes, and low expression in heart, spleen, kidney, and placenta. {ECO:0000269PubMed:18554506}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016829 lyase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007482 Protein-tyrosine phosphatase-like, PTPLA
PFAM PF04387
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VWC8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 401494
UniGene Hs.733096
RefSeq NP_001010915
HUGO HGNC:20920
OMIM 615941
CCDS CCDS43791
HPRD 17392
IMGT
EMBL AL390882 BC114215 BX538052 CH471071
GenPept AAI14216 CAD97990 CAH70162 EAW58626

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca