InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC14B

Summary

InnateDB Protein

IDBP-484785.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC14B

Protein Name

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

Synonyms

Cdc14B1; Cdc14B2; CDC14B3; hCDC14B;

Species

Homo sapiens

Ensembl Protein

ENSP00000417897

InnateDB Gene

IDBG-77419 (CDC14B)

Protein Structure

UniProt Annotation

Function

Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269PubMed:17488717, ECO:0000269PubMed:18662541, ECO:0000269PubMed:9367992}.

Subcellular Localization

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006281	DNA repair
GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0031572	G2 DNA damage checkpoint
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0051488	activation of anaphase-promoting complex activity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt