InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSNK1G3

Summary

InnateDB Protein

IDBP-484794.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK1G3

Protein Name

casein kinase 1, gamma 3

Synonyms

CKI-gamma 3; CSNK1G3L;

Species

Homo sapiens

Ensembl Protein

ENSP00000429412

InnateDB Gene

IDBG-39178 (CSNK1G3)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006464	cellular protein modification process
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022247 Casein kinase 1 gamma C-terminal

PFAM

PF00069
PF07714
PF12605

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt