InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PATL1

Summary

InnateDB Protein

IDBP-48484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PATL1

Protein Name

protein associated with topoisomerase II homolog 1 (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300146

InnateDB Gene

IDBG-48482 (PATL1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269PubMed:17936923, ECO:0000269PubMed:19628699, ECO:0000269PubMed:20543818, ECO:0000269PubMed:20584987, ECO:0000269PubMed:20852261}.

Subcellular Localization

Cytoplasm, P-body. Nucleus. Nucleus, PML body. Nucleus speckle. Note=Predominantly cytoplasmic. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:17936923}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008266	poly(U) RNA binding
GO:0034046	poly(G) binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005829	cytosol
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0030014	CCR4-NOT complex
GO:0043231	intracellular membrane-bounded organelle