Version 5.4
Homo sapiens Protein: MALSU1
Summary
InnateDB Protein IDBP-484872.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MALSU1
Protein Name chromosome 7 open reading frame 30
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000419370
InnateDB Gene IDBG-9662 (MALSU1)
Protein Structure
UniProt Annotation
Function May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. {ECO:0000269PubMed:22238376}.
Subcellular Localization Mitochondrion matrix {ECO:0000269PubMed:16548050, ECO:0000269PubMed:22238375, ECO:0000269PubMed:22238376, ECO:0000269PubMed:22829778}. Note=Colocalizes with MRPL12 (PubMed:22238375) and/or MRPL14 (PubMed:22829778). {ECO:0000269PubMed:22238375, ECO:0000269PubMed:22829778}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0042273 ribosomal large subunit biogenesis
GO:0070130 negative regulation of mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR004394 Protein Iojap/ribosomal silencing factor RsfS
IPR025656 Oligomerisation domain
PFAM PF02410
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EH3
PhosphoSite PhosphoSite-Q96EH3
TrEMBL
UniProt Splice Variant
Entrez Gene 115416
UniGene Hs.87385
RefSeq NP_612455
HUGO HGNC:21721
OMIM 614624
CCDS CCDS5381
HPRD 12918
IMGT
EMBL AC005082 AK127742 AK316559 BC012331 CH236948 CH471073
GenPept AAH12331 BAG38148 BAG54562 EAL24258 EAW93785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca