InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACTR8

Summary

InnateDB Protein

IDBP-485030.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTR8

Protein Name

ARP8 actin-related protein 8 homolog (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419429

InnateDB Gene

IDBG-40529 (ACTR8)

Protein Structure

UniProt Annotation

Function

Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18163988}. Chromosome {ECO:0000269PubMed:18163988}. Note=Specifically localizes to mitotic chromosomes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007067	mitotic nuclear division