Version 5.4
Homo sapiens Protein: CST7
Summary
InnateDB Protein IDBP-485420.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CST7
Protein Name cystatin F (leukocystatin)
Synonyms CMAP;
Species Homo sapiens
Ensembl Protein ENSP00000420384
InnateDB Gene IDBG-60667 (CST7)
Protein Structure
UniProt Annotation
Function Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
Subcellular Localization Secreted {ECO:0000269PubMed:12423348}. Cytoplasm {ECO:0000269PubMed:12423348}.
Disease Associations
Tissue Specificity Primarily expressed in peripheral blood cells and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O76096
PhosphoSite PhosphoSite-O76096
TrEMBL
UniProt Splice Variant
Entrez Gene 8530
UniGene
RefSeq NP_003641
HUGO HGNC:2479
OMIM 603253
CCDS CCDS13165
HPRD 04458
IMGT
EMBL AB015225 AB029636 AF031824 AF036342 AJ510167 AJ510168 AJ510169 AJ510170 AL035661 BC015507 BT009825 CR541860 CR541878
GenPept AAC35747 AAC39788 AAH15507 AAP88827 BAA34941 BAB11886 CAB75498 CAD52872 CAG46658 CAG46676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca