InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMUG1

Summary

InnateDB Protein

IDBP-485510.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMUG1

Protein Name

single-strand-selective monofunctional uracil-DNA glycosylase 1

Synonyms

FDG; HMUDG; UNG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000421206

InnateDB Gene

IDBG-37516 (SMUG1)

Protein Structure

UniProt Annotation

Function

Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5- hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. {ECO:0000269PubMed:10074426, ECO:0000269PubMed:11526119, ECO:0000269PubMed:12161446, ECO:0000269PubMed:12718543}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10074426, ECO:0000269PubMed:12161446}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004844	uracil DNA N-glycosylase activity
GO:0005515	protein binding
GO:0017065	single-strand selective uracil DNA N-glycosylase activity
GO:0019104	DNA N-glycosylase activity