InnateDB Protein
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IDBP-485560.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPH5
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Protein Name
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DPH5 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000418282
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InnateDB Gene
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IDBG-100546 (DPH5)
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Protein Structure
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Function |
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EEF2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. {ECO:0000269PubMed:23486472}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000878
Tetrapyrrole methylase
IPR004551
Diphthine synthase
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PFAM |
PF00590
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PRINTS |
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PIRSF |
PIRSF036432
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H2P9
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PhosphoSite |
PhosphoSite-Q9H2P9
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TrEMBL |
Q96DC6
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UniProt Splice Variant |
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Entrez Gene |
51611
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UniGene |
Hs.440776
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RefSeq |
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HUGO |
HGNC:24270
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OMIM |
611075
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CCDS |
CCDS41358
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HPRD |
13037
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IMGT |
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EMBL |
AC093157
AF132964
AF157319
AF161492
AF248965
AK125485
AK289351
BC009620
BC053857
CH471097
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GenPept |
AAD27739
AAF29107
AAF67485
AAG44563
AAH09620
AAH53857
BAF82040
BAG54203
EAW72933
EAW72934
EAW72936
EAW72937
EAW72938
EAW72940
EAW72941
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