InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPP1R12B

Summary

InnateDB Protein

IDBP-485622.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1R12B

Protein Name

protein phosphatase 1, regulatory subunit 12B

Synonyms

MYPT2; PP1bp55;

Species

Homo sapiens

Ensembl Protein

ENSP00000417159

InnateDB Gene

IDBG-105846 (PPP1R12B)

Protein Structure

UniProt Annotation

Function

Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus. {ECO:0000269PubMed:11067852, ECO:0000269PubMed:9570949}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12923170}. Note=Along actomyosin filaments and stress fibers.

Disease Associations

Tissue Specificity

Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific. {ECO:0000269PubMed:11067852, ECO:0000269PubMed:9570949}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006937	regulation of muscle contraction
GO:0007165	signal transduction
GO:0043085	positive regulation of catalytic activity