InnateDB Protein
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IDBP-48570.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EIF4EBP3
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Protein Name
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eukaryotic translation initiation factor 4E binding protein 3
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Synonyms
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4E-BP3; 4EBP3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000308472
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InnateDB Gene
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IDBG-409438 (EIF4EBP3)
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Protein Structure
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Function |
Regulates eIF4E activity by preventing its assembly into the eIF4F complex.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus. {ECO:0000269PubMed:9593750}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0045947
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negative regulation of translational initiation
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Cellular Component |
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PDB ID |
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InterPro |
IPR008606
Eukaryotic translation initiation factor 4E binding
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PFAM |
PF05456
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O60516
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PhosphoSite |
PhosphoSite-O60516
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8637
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UniGene |
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RefSeq |
NP_003723
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HUGO |
HGNC:3290
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OMIM |
603483
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CCDS |
CCDS4226
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HPRD |
09149
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IMGT |
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EMBL |
AF038869
BC010881
BC069293
BC073751
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GenPept |
AAC39761
AAH10881
AAH69293
AAH73751
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