Version 5.4
Homo sapiens Protein: KRTAP1-3
Summary
InnateDB Protein IDBP-48598.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRTAP1-3
Protein Name keratin associated protein 1-3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000344420
InnateDB Gene IDBG-281648 (KRTAP1-3)
Protein Structure
UniProt Annotation
Function In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. {ECO:0000269PubMed:11279113}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0030280 structural constituent of epidermis
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0045095 keratin filament
Protein Structure and Domains
PDB ID
InterPro IPR002494 Keratin-associated protein
PFAM PF01500
PF13885
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IUG1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 81850
UniGene Hs.534495
RefSeq NP_112228
HUGO HGNC:16771
OMIM 608820
CCDS CCDS42323
HPRD 12305
IMGT
EMBL AB081338 AB081339 AJ406927 BC069161 BC101150 BC101151 BC101152 BC101153 X63338
GenPept AAH69161 AAI01151 AAI01152 AAI01153 AAI01154 BAC15619 BAC15620 CAA44938 CAC27566

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca