Version 5.4
Homo sapiens Protein: KRTAP1-5
Summary
InnateDB Protein IDBP-48600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRTAP1-5
Protein Name keratin associated protein 1-5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355302
InnateDB Gene IDBG-281647 (KRTAP1-5)
Protein Structure
UniProt Annotation
Function In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone. {ECO:0000269PubMed:11279113}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0045095 keratin filament
Protein Structure and Domains
PDB ID
InterPro IPR002494 Keratin-associated protein
PFAM PF01500
PF13885
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BYS1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 83895
UniGene Hs.534499
RefSeq NP_114163
HUGO HGNC:16777
OMIM 608822
CCDS CCDS42321
HPRD 12306
IMGT
EMBL AC007455 AJ406928 BC069533 BC093841 BC101555 CH471152
GenPept AAH69533 AAH93841 AAI01556 CAC27567 EAW60697

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca