Version 5.4
Homo sapiens Protein: OXER1
Summary
InnateDB Protein IDBP-48605.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OXER1
Protein Name oxoeicosanoid (OXE) receptor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000367930
InnateDB Gene IDBG-48603 (OXER1)
Protein Structure
UniProt Annotation
Function Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins. {ECO:0000269PubMed:12065583, ECO:0000269PubMed:12606753}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed in various tissues except brain. Expression is more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. Highly expressed in eosinophils, neutrophils, and lung macrophages. {ECO:0000269PubMed:12065583, ECO:0000269PubMed:12606753}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0050646 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
GO:0050647 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
GO:0050648 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0030817 regulation of cAMP biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDS5
PhosphoSite PhosphoSite-Q8TDS5
TrEMBL
UniProt Splice Variant
Entrez Gene 165140
UniGene Hs.168439
RefSeq NP_683765
HUGO HGNC:24884
OMIM
CCDS CCDS1810
HPRD 17812
IMGT
EMBL AB065652 AB083055 AB083630 AC098824 AY158687 BC063549
GenPept AAH63549 AAO17739 AAY14700 BAB89343 BAC05878 BAC11806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca