InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TCN1

Summary

InnateDB Protein

IDBP-48701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TCN1

Protein Name

transcobalamin I (vitamin B12 binding protein, R binder family)

Synonyms

HC; TC-1; TC1; TCI;

Species

Homo sapiens

Ensembl Protein

ENSP00000257264

InnateDB Gene

IDBG-48699 (TCN1)

Protein Structure

UniProt Annotation

Function

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils. {ECO:0000269PubMed:2777761}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0031419	cobalamin binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006824	cobalt ion transport
GO:0009235	cobalamin metabolic process
GO:0015889	cobalamin transport
GO:0044281	small molecule metabolic process