InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPEF1

Summary

InnateDB Protein

IDBP-48790.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPEF1

Protein Name

protein phosphatase, EF-hand calcium binding domain 1

Synonyms

PP7; PPEF; PPP7C; PPP7CA;

Species

Homo sapiens

Ensembl Protein

ENSP00000354871

InnateDB Gene

IDBG-48786 (PPEF1)

Protein Structure

UniProt Annotation

Function

May have a role in the recovery or adaptation response of photoreceptors. May have a role in development.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in retina and retinal derived Y-79 retinoblastoma cells. Also found in fetal brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005506	iron ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007603	phototransduction, visible light
GO:0016056	rhodopsin mediated signaling pathway
GO:0016311	dephosphorylation
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0050906	detection of stimulus involved in sensory perception

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR002048 EF-hand domain
IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR012008 Serine/threonine protein phosphatase, EF-hand-containing
IPR013235 PPP domain
IPR029052 Metallo-dependent phosphatase-like

PFAM

PF00612
PF00036
PF13202
PF13405
PF00149
PF08321

PRINTS

PR00114

PIRSF

PIRSF000912

SMART

SM00015
SM00054
SM00156

TIGRFAMs

Post-translational Modifications

Modification

Cross-References