InnateDB Protein
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IDBP-48888.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MS4A2
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Protein Name
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membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
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Synonyms
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APY; ATOPY; FCER1B; FCERI; IGEL; IGER; IGHER; MS4A1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000278888
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InnateDB Gene
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IDBG-48886 (MS4A2)
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Protein Structure
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Function |
High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Found on the surface of mast cells and basophils.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007237
CD20-like
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PFAM |
PF04103
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q01362
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PhosphoSite |
PhosphoSite-Q01362
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TrEMBL |
E9PLJ1
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UniProt Splice Variant |
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Entrez Gene |
2206
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UniGene |
Hs.386748
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RefSeq |
NP_000130
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HUGO |
HGNC:7316
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OMIM |
147138
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CCDS |
CCDS7980
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HPRD |
00915
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IMGT |
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EMBL |
AB080913
AP001181
BC074800
BC074843
D10583
M89796
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GenPept |
AAA60269
AAH74800
AAH74843
BAA01440
BAC66486
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