InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP5S1

Summary

InnateDB Protein

IDBP-49038.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP5S1

Protein Name

chromosome 20 open reading frame 29

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000368886

InnateDB Gene

IDBG-49032 (AP5S1)

Protein Structure

UniProt Annotation

Function

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair. {ECO:0000269PubMed:20613862, ECO:0000269PubMed:22022230}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:22022230}. Late endosome membrane {ECO:0000305PubMed:22022230}; Peripheral membrane protein {ECO:0000305PubMed:22022230}; Cytoplasmic side {ECO:0000305PubMed:22022230}. Lysosome membrane {ECO:0000305PubMed:22022230}; Peripheral membrane protein {ECO:0000305PubMed:22022230}; Cytoplasmic side {ECO:0000305PubMed:22022230}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0015031	protein transport
GO:0016197	endosomal transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005829	cytosol
GO:0030119	AP-type membrane coat adaptor complex
GO:0031902	late endosome membrane