Version 5.4
Homo sapiens Protein: TRAT1
Summary
InnateDB Protein IDBP-49133.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAT1
Protein Name T cell receptor associated transmembrane adaptor 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000295756
InnateDB Gene IDBG-49131 (TRAT1)
Protein Structure
UniProt Annotation
Function Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. {ECO:0000269PubMed:11390434}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:9687533}; Single-pass type III membrane protein {ECO:0000269PubMed:9687533}.
Disease Associations
Tissue Specificity Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level). {ECO:0000269PubMed:16160011, ECO:0000269PubMed:9687533}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process
GO:0001920 negative regulation of receptor recycling
GO:0006968 cellular defense response
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0051051 negative regulation of transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0042101 T cell receptor complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PIZ9
PhosphoSite PhosphoSite-Q6PIZ9
TrEMBL
UniProt Splice Variant
Entrez Gene 50852
UniGene Hs.138701
RefSeq NP_057472
HUGO HGNC:30698
OMIM 604962
CCDS CCDS33813
HPRD 05392
IMGT
EMBL AF161547 BC025713
GenPept AAF29034 AAH25713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca