InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GUCA1C

Summary

InnateDB Protein

IDBP-49185.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCA1C

Protein Name

guanylate cyclase activator 1C

Synonyms

GCAP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000261047

InnateDB Gene

IDBG-49183 (GUCA1C)

Protein Structure

UniProt Annotation

Function

Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.

Subcellular Localization

Disease Associations

Tissue Specificity

Retina.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0008048	calcium sensitive guanylate cyclase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0031284	positive regulation of guanylate cyclase activity