Homo sapiens Protein: CALML3
Summary
InnateDB Protein IDBP-49196.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALML3
Protein Name calmodulin-like 3
Synonyms CLP;
Species Homo sapiens
Ensembl Protein ENSP00000315299
InnateDB Gene IDBG-49192 (CALML3)
Protein Structure
UniProt Annotation
Function May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates. {ECO:0000269PubMed:11278607, ECO:0000269PubMed:18295593}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells. {ECO:0000269PubMed:2217169}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive
PFAM PF00036
PF13202
PF13405
PF08726
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P27482
PhosphoSite PhosphoSite-P27482
TrEMBL
UniProt Splice Variant
Entrez Gene 810
UniGene Hs.239600
RefSeq NP_005176
HUGO HGNC:1452
OMIM 114184
CCDS CCDS7069
HPRD 00244
IMGT
EMBL AK313934 AL732437 BC031889 CH471072 M58026 X13461
GenPept AAA36356 AAH31889 BAG36653 CAA31809 CAI11029 EAW86443