InnateDB Protein
|
IDBP-49376.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PTGDR2
|
Protein Name
|
G protein-coupled receptor 44
|
Synonyms
|
CD294; CRTH2; DL1R; DP2; GPR44;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000332812
|
InnateDB Gene
|
IDBG-49374 (PTGDR2)
|
Protein Structure
|
|
Function |
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269PubMed:11208866, ECO:0000269PubMed:11535533, ECO:0000269PubMed:17196174}.
|
Subcellular Localization |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269PubMed:17207480}.
|
Disease Associations |
|
Tissue Specificity |
Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. {ECO:0000269PubMed:11168006, ECO:0000269PubMed:11208866, ECO:0000269PubMed:12466225, ECO:0000269PubMed:9973380}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
GO:0006935
|
chemotaxis
|
GO:0006955
|
immune response
|
GO:0007186
|
G-protein coupled receptor signaling pathway
|
GO:0007193
|
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
|
GO:0019722
|
calcium-mediated signaling
|
GO:0045745
|
positive regulation of G-protein coupled receptor protein signaling pathway
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR002234
Anaphylatoxin chemotactic receptor family
IPR017452
GPCR, rhodopsin-like, 7TM
|
PFAM |
PF00001
|
PRINTS |
PR00237
PR01104
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9Y5Y4
|
PhosphoSite |
PhosphoSite-Q9Y5Y4
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
11251
|
UniGene |
Hs.299567
|
RefSeq |
NP_004769
|
HUGO |
HGNC:4502
|
OMIM |
604837
|
CCDS |
CCDS7994
|
HPRD |
16075
|
IMGT |
|
EMBL |
AB008535
AF118265
AF144308
AP000777
AY507142
BC096841
|
GenPept |
AAD21055
AAD34539
AAH96841
AAR92484
BAA74518
|
|
|