InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC10A2

Summary

InnateDB Protein

IDBP-49422.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC10A2

Protein Name

solute carrier family 10 (sodium/bile acid cotransporter family), member 2

Synonyms

ASBT; IBAT; ISBT; NTCP2; PBAM;

Species

Homo sapiens

Ensembl Protein

ENSP00000245312

InnateDB Gene

IDBG-49420 (SLC10A2)

Protein Structure

UniProt Annotation

Function

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Primary bile acid malabsorption (PBAM) [MIM:613291]: An intestinal disorder associated with chronic watery diarrhea, excess fecal bile acids, steatorrhea and interruption of the enterohepatic circulation of bile acids. {ECO:0000269PubMed:9109432}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008508	bile acid:sodium symporter activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0008206	bile acid metabolic process
GO:0015711	organic anion transport
GO:0015721	bile acid and bile salt transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005902	microvillus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane