Version 5.4
Homo sapiens Protein: CHPF2
Summary
InnateDB Protein IDBP-49425.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHPF2
Protein Name chondroitin polymerizing factor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000035307
InnateDB Gene IDBG-49423 (CHPF2)
Protein Structure
UniProt Annotation
Function Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N- acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N- acetylgalactosaminyltransferase activity. {ECO:0000269PubMed:12145278, ECO:0000269PubMed:18316376}.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in placenta, small intestine and pancreas. {ECO:0000269PubMed:12145278}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008376 acetylgalactosaminyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0030203 glycosaminoglycan metabolic process
GO:0030204 chondroitin sulfate metabolic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Protein Structure and Domains
PDB ID
InterPro IPR003378 Fringe-like
IPR008428 Chondroitin N-acetylgalactosaminyltransferase
PFAM PF02434
PF05679
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2E5
PhosphoSite PhosphoSite-Q9P2E5
TrEMBL
UniProt Splice Variant
Entrez Gene 54480
UniGene Hs.647084
RefSeq NP_061888
HUGO HGNC:29270
OMIM 608037
CCDS CCDS34779
HPRD 10474
IMGT
EMBL AB037823 AB095812 AY358407 BC064509 CH471173
GenPept AAH64509 AAQ88773 BAA92640 BAG30817 EAW54011

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca