InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GDI2

Summary

InnateDB Protein

IDBP-49563.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GDI2

Protein Name

GDP dissociation inhibitor 2

Synonyms

HEL-S-46e; RABGDIB;

Species

Homo sapiens

Ensembl Protein

ENSP00000369538

InnateDB Gene

IDBG-49561 (GDI2)

Protein Structure

UniProt Annotation

Function

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:7543319}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005093	Rab GDP-dissociation inhibitor activity
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0031267	small GTPase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0032851	positive regulation of Rab GTPase activity
GO:0050790	regulation of catalytic activity
GO:0051056	regulation of small GTPase mediated signal transduction