InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHEB

Summary

InnateDB Protein

IDBP-49650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHEB

Protein Name

Ras homolog enriched in brain

Synonyms

RHEB2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262187

InnateDB Gene

IDBG-49648 (RHEB)

Protein Structure

UniProt Annotation

Function

Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity. {ECO:0000269PubMed:12271141, ECO:0000269PubMed:12869586, ECO:0000269PubMed:15340059, ECO:0000269PubMed:15854902, ECO:0000269PubMed:16098514, ECO:0000269PubMed:20381137}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Ubiquitous. Highest levels observed in skeletal and cardiac muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	52 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0019901	protein kinase binding
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0015031	protein transport
GO:0032008	positive regulation of TOR signaling

Cellular Component

GO:0005622	intracellular
GO:0005681	spliceosomal complex
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt