InnateDB Protein
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IDBP-49738.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GCSAM
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Protein Name
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germinal center expressed transcript 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000309487
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InnateDB Gene
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IDBG-49736 (GCSAM)
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Protein Structure
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Function |
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269PubMed:17823310, ECO:0000269PubMed:20844236, ECO:0000269PubMed:23299888}.
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Subcellular Localization |
Cytoplasm. Cell membrane. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
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Disease Associations |
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Tissue Specificity |
Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen. {ECO:0000269PubMed:12509382, ECO:0000269PubMed:12819018, ECO:0000269PubMed:15677569}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0050855
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regulation of B cell receptor signaling pathway
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GO:2000402
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negative regulation of lymphocyte migration
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N6F7
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PhosphoSite |
PhosphoSite-Q8N6F7
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TrEMBL |
C9JY41
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UniProt Splice Variant |
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Entrez Gene |
257144
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UniGene |
Hs.49614
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RefSeq |
NP_689998
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HUGO |
HGNC:20253
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OMIM |
607792
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CCDS |
CCDS2964
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HPRD |
09695
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IMGT |
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EMBL |
AC128688
AF521911
AY212246
BC030506
BM456595
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GenPept |
AAH30506
AAO21701
AAO22147
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