InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC9C1

Summary

InnateDB Protein

IDBP-49757.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9C1

Protein Name

solute carrier family 9, member 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000306627

InnateDB Gene

IDBG-49755 (SLC9C1)

Protein Structure

UniProt Annotation

Function

Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, cilium, flagellum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015299	solute:proton antiporter activity

Biological Process

GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0030317	sperm motility
GO:0034220	ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport