Version 5.4
Homo sapiens Protein: CCDC59
Summary
InnateDB Protein IDBP-49783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCDC59
Protein Name coiled-coil domain containing 59
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000256151
InnateDB Gene IDBG-49781 (CCDC59)
Protein Structure
UniProt Annotation
Function Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities. {ECO:0000269PubMed:12882447, ECO:0000269PubMed:16630564}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells. {ECO:0000269PubMed:11152647}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR013730 rRNA processing
PFAM PF08524
PRINTS PR01854
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P031
PhosphoSite PhosphoSite-Q9P031
TrEMBL
UniProt Splice Variant
Entrez Gene 29080
UniGene Hs.606671
RefSeq NP_054886
HUGO HGNC:25005
OMIM
CCDS CCDS9023
HPRD 13696
IMGT
EMBL AF161477 AF213377 AK001156 BC020647
GenPept AAF29092 AAG43569 AAH20647 BAA91524

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca