InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF13

Summary

InnateDB Protein

IDBP-4979.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF13

Protein Name

Kruppel-like factor 13

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000302456

InnateDB Gene

IDBG-4977 (KLF13)

Protein Structure

UniProt Annotation

Function

Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. {ECO:0000269PubMed:11477107}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter