Version 5.4
Homo sapiens Protein: PGA5
Summary
InnateDB Protein IDBP-49826.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGA5
Protein Name pepsinogen 5, group I (pepsinogen A)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000309542
InnateDB Gene IDBG-544587 (PGA5)
Protein Structure
UniProt Annotation
Function Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0007586 digestion
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR001461 Aspartic peptidase
IPR012848 Aspartic peptidase, N-terminal
IPR021109 Aspartic peptidase domain
PFAM PF00026
PF07966
PRINTS PR00792
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P0DJD9
PhosphoSite PhosphoSite-P0DJD9
TrEMBL F5GWT0
UniProt Splice Variant
Entrez Gene 5222
UniGene
RefSeq NP_055039
HUGO HGNC:8887
OMIM 169730
CCDS CCDS8001
HPRD 01356
IMGT
EMBL AP003037 BC029055 BC146999 BC171889 CH471076 M26025 M26026 M26027 M26028 M26029 M26030 M26031 M26032
GenPept AAA60061 AAH29055 AAI47000 AAI71889 EAW73928

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca