InnateDB Protein
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IDBP-49846.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC6A15
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Protein Name
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solute carrier family 6 (neutral amino acid transporter), member 15
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000266682
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InnateDB Gene
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IDBG-49844 (SLC6A15)
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Protein Structure
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Function |
Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269PubMed:16226721}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Almost exclusively expressed in the brain. {ECO:0000269PubMed:16226721}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005298
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proline:sodium symporter activity
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GO:0005326
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neurotransmitter transporter activity
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GO:0005328
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neurotransmitter:sodium symporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000175
Sodium:neurotransmitter symporter
IPR002438
Sodium:neurotransmitter symporter, orphan
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PFAM |
PF00209
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PRINTS |
PR00176
PR01206
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H2J7
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PhosphoSite |
PhosphoSite-Q9H2J7
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TrEMBL |
Q68CX0
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UniProt Splice Variant |
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Entrez Gene |
55117
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UniGene |
Hs.44424
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RefSeq |
NP_877499
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HUGO |
HGNC:13621
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OMIM |
607971
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CCDS |
CCDS9026
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HPRD |
12141
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IMGT |
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EMBL |
AC018922
AC128657
AF265577
AK022853
AK291207
AK294945
BC070040
CH471054
CR749673
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GenPept |
AAG41361
AAH70040
BAB14274
BAF83896
BAH11933
CAH18464
EAW97389
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